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- W2393058438 abstract "Objective To investigate the neuroanatomic basis of depression and its mechanism Methods The distribution of fos like immunoreactive (FLI) neurons in telencephalon, diencephalon, midbrain and pons were examined in 10 “behavioral despair” (BD) rats and 10 “simple forced swimming” (SFS) rats, and the distributions of FLI neurons of the two groups were compared by fos Ab immunohistochemistry methods Results The distribution of FLI neurons increased in prefrontal medial cortex ( P 0 01), lateral septal nucleus ( P 0 01), hypothalamic paraventricular nucleus ( P 0 05), lateral hypothalamic area ( P 0 01), mesencephalic centre grey matter ( P 0 01), mesencephalic reticular formation ( P 0 01) and dorsal raphe nucleus ( P 0 01) in BD rats compared with SFS rats The dark cell nucleus and light cell cytoplasm of FLI cell body were examined in frontal cortex V, mesencephalic reticular formation and dorsal raphe nucleus in BD rat Conclusions The results suggest that the mechanism of depression is involved in a strongly and persistently excited reward system in brain, which induce cellular Ca 2+ overloading, and degeneration of neurons" @default.
- W2393058438 created "2016-06-24" @default.
- W2393058438 creator A5013614593 @default.
- W2393058438 date "2000-01-01" @default.
- W2393058438 modified "2023-09-23" @default.
- W2393058438 title "The distribution of fos like immunoreactive neurons in the brain of “behavioral despair”rats" @default.
- W2393058438 hasPublicationYear "2000" @default.
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