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- W2393058673 abstract "OBJECTIVE To investigate the effect of electrostatic force on the complexation of ionized cyclodextrins with dissociated drugs in aqueous solution and further explore the complexing mechanism.METHODS Norfloxacin(NFX) was uesd as a model drug,and SBE-β-CD as a complexing material.The UV spectra of NFX,phase solubility diagrams,complex stability constants(Ka) and thermodynamic parameters for the drug complexation with SBE-β-CD in aqueous solutions were determined and compared under acid,neutral and alkaline pHs,respectively.RESULTS The UV spectra of NFX,phase solubility diagrams,Ka were obvious different at above three different pHs,but the thermodynamic parameter values for the complexation process such as △G,△H and △S were all negative,indicating that the mechanisms for the complexation process of complexation seemed to be unchanged.CONCLUSION For the charged cyclodextrin and ionized drugs,electrostatic effect is one of main host-guest molecular forces and the media pH will exert an imprtant influence on the complexation process." @default.
- W2393058673 created "2016-06-24" @default.
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- W2393058673 date "2011-01-01" @default.
- W2393058673 modified "2023-09-25" @default.
- W2393058673 title "Effect of electrostatic force on the complexation of ionized cyclodextrins with dissociated drugs in aqueous solution" @default.
- W2393058673 hasPublicationYear "2011" @default.
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