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- W2393059388 abstract "Objective To investigate the role of interleukin-32 in chronic obstructive pulmonary disease(COPD) by detecting the levels of interleukin-32 in the serum and induced sputum in patients with COPD.Methods Sixty patients with acute exacerbation of COPD,sixty patients with stable COPD and thirty healthy subjects were recruited.The concentrations of interleukin-32,interleukin-8 and tumor necrosis factor-alpha(TNF-α) in serum and induced sputum were measured with enzyme-linked immunosorbent assay(ELISA).The correlations among interleukin-32,neutrophil,interleukin-8,TNF-α and lung functions were investigated.Results The levels of interleukin-32 in serum and sputum were significantly higher in acute exacerbation of COPD than those in healthy subjects and in stable COPD patients(P0.05),and were higher in stable COPD patients than those in healthy subjects(P0.05).The levels of interleukin-32 in serum and sputum were positively correlated with the levels of interleukin-8,TNF-α,and neutrophil count and percentage(P0.01),and were negatively correlated with forced expiatory volume in one second(FEV1)/predicted values,FEV1/forced vital capacity and pa(O2)(P0.01).Conclusion Interleukin-32 may be involved in the pathogenesis of airway inflammation in COPD.Interleukin-32 may be a noninvasive marker of severity of COPD." @default.
- W2393059388 created "2016-06-24" @default.
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- W2393059388 date "2012-01-01" @default.
- W2393059388 modified "2023-09-27" @default.
- W2393059388 title "Changes and significance of interleukin-32 in the serum and induced sputum in chronic obstructive pulmonary disease" @default.
- W2393059388 hasPublicationYear "2012" @default.
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