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- W2393059655 abstract "To investigate the effect of miR-150 on pulmonary hemorrhage in pristane-induced murine lupus model and to explore the possible mechanism,C57/B6 mice and miR-150-deficient mice received a single dose of 0.5 ml pristane intraperitoneally at eight-weeks old.After 7 days,10 days,14 days,pulmonary hemorrhage was investigated by gross pathology and hematoxylin-eosin stain scores.We found that both C57/B6 group and miR-150-deficient group suffered pulmonary hemorrhage,and miR-150-deficient group was more serious than C57/B6 group 10 days and 14 days after injection of pristane.In addition,compared to C57/B6 group,its histological score is higher.Then,the quantification of TNF-α in serum was performed by sandwich enzymed-linked immune absorbent assay(ELISA) and the right upper lobe of the lung was weighted before and after drying.Results showed that expression of TNF-α in the serum and W/D ratio of miR-150-deficient group was higher revealing that miR-150 participates the pathogenesis of pulmonary hemorrhage in pristane-induced murine lupus model and hopefully be a forcasting biomarker of pulmonary hemorrhage of lupus." @default.
- W2393059655 created "2016-06-24" @default.
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- W2393059655 date "2012-01-01" @default.
- W2393059655 modified "2023-09-22" @default.
- W2393059655 title "Influence of miR-150 on pulmonary hemorrhage in pristane-induced murine lupus model" @default.
- W2393059655 hasPublicationYear "2012" @default.
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