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- W2393061208 abstract "Objective To explore the change of serum Cyfra21- 1、CEA、NSE levels in different degrees of bone metastases of lung cancer and evaluation of accuracy in diagnosing bone metastasis by mensuring the level of soluble fragment Cyfra21- 1 of cytokeratin 19( CK19),carcinoembryonic antigen( CEA) and neuronspecific enolase( NSE). Methods 101 lung cancer patients confirmed by pathology or needle biopsy were underwent whole body bone images,and divided into without bone metastases( 52 persons),single- bone metastases( 19 persons) and multiplt- bone metastases( 30 persons) groups according to the different degrees of bone metastasis. We detected the levels of serum Cyfra21- 1、CEA、NSE of 101 patients and 30 lung benign disease patients and compared the change of tumor makers' level in each group,evaluation of accuracy in diagnosing bone metastasis by receiver operating characteristic curve. Results The level of serum Cyfra21- 1、CEA、NSE in lung cancer group were much higher than lung benign disease( P 0. 01),the level of serum Cyfra21- 1、CEA、NSE in lung cancer with bone metastasis group were much higher than without bone metastasis( P 0. 01),and multiplt- bone metastases were much higher than single- bone metastases( P 0. 05),The area under the curve of surem Cyfra21- 1、CEA 、NSE were 0. 767,0. 850,0. 813,The serum Cyfra21- 1 and CEA had the highest sensitivity that is 91. 8%,the serum NSE of the highest specificity,73. 10%. Conclusion Serum Cyfra21- 1,CEA,NSE has a higher accuracy in diagnosing bone metastasis of lung cancer,and can be used as a method in screening and monitoring bone metastasis." @default.
- W2393061208 created "2016-06-24" @default.
- W2393061208 creator A5065914345 @default.
- W2393061208 date "2014-01-01" @default.
- W2393061208 modified "2023-09-25" @default.
- W2393061208 title "The change of serum Cyfra21- 1,CEA,NSE levels in bone metastases of lung cancer and its evaluation of accuracy" @default.
- W2393061208 hasPublicationYear "2014" @default.
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