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- W2393065375 abstract "OBJECTIVE To observe effect of doxazosin enantiomers on functions of rats′ isolated atrium and ventricle.METHODS The isolated right atrium,left atrium and right ventricle strip of rats were prepared.Doxazosin enantiomers 3,10 and 30 μmol·L-1 were cumulatively applied to isolated atrium preparation of rats but were non-cumulatively applied to isolated right ventricle preparation of rats.Effects of doxazosin enantiomers on the contractile force and heart rate were observed.RESULTS S-Dox 3-10 μmol·L-1 did not induce cardiac arrest,while R-Dox and rac-Dox induced cardiac arrest by 28% and 7%,respectively.S-Dox 3-30 μmol·L-1 did not affect the heart rate of the isolated right atrium of rats,while R-Dox and rac-Dox decreased the heart rate.S-Dox 3-30 μmol·L-1 concentration-dependently increased the contractile force of isolated left atrium.R-Dox and rac-Dox at the same concentration decreased the contractile force of the isolated left atrium in a concentration-dependent manner.CONCLUSION rac-Dox 3-10 μmol·L-1 induces cardiac arrest and its heart toxicity is related to R-Dox.S-Dox at the same concentration does not induce cardiac arrest.S-Dox 3-30 μmol·L-1 has no effect on the contractile force of the isolated right ventricle strip,while R-Dox and rac-Dox concentration-dependently decrease the contractile force of the isolated right ventricle strip.There is difference between the action mechanism of R-Dox and S-Dox in isolated heart muscle of rats." @default.
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- W2393065375 date "2012-01-01" @default.
- W2393065375 modified "2023-09-26" @default.
- W2393065375 title "Effect of doxazosin enantiomers on mechanical performance of isolated heart muscle of rats" @default.
- W2393065375 hasPublicationYear "2012" @default.
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