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- W2393066499 abstract "Objective This study aimed to investigate the role of inducible NOS (iNOS) and endothelial NOS (eNOS) in acute lung injury caused by intestinal ischemia/reperfusion.Methods Sprague Dawley rats were randomized into six groups.All rats underwent either superior mesenteric artery (SMA) occlusion (60?min) and 60?min (Group A),120?min (Group B) and 240?min (Group C) reperfusion separately or sham operation (Control group AC,BC,CC).Pulmonary microvascular permeability was evaluated by Evans blue dye concentration.Intestinal injury was assessed by histological method.The expression of pulmonary NOS (iNOS and eNOS) and its?mRNA were assessed by RT PCR and Western blot.Small bowel was harvested for histological examination and lung tissue was taken for molecular biological study.Results The pulmonary Evans blue dye concentration was significantly increased in all the study groups compared with their control ones.Based on the result of histology,the classification of bowel injury was as increased as prolonging reperfusion time and different significantly among the groups of A,B and C.Expression of pulmonary iNOS was significantly elevated in all the study groups,especially in Group C (vs Group A, P 0.05).The positive correlation was found in iNOS expression with reperfusion time and pulmonary microvascular permeability.No statistical difference was found in the changes of pulmonary eNOS in study groups.Conclusion Intestinal ischemia/reperfusion can lead to acute lung injury by producing iNOS substance.The level of pulmonary iNOS has positive correlation with pulmonary microvascular permeability and reperfusion time.These data reveal that iNOS may play an important role in acute lung injury induced by intestinal ischemia/reperfusion." @default.
- W2393066499 created "2016-06-24" @default.
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- W2393066499 date "2004-01-01" @default.
- W2393066499 modified "2023-09-25" @default.
- W2393066499 title "The expression and role of NOS in acute lung injury caused by intestinal ischemia" @default.
- W2393066499 hasPublicationYear "2004" @default.
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