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- W2393068605 abstract "ObjectiveTo comparatively study the preventive effects of gelatinizedly-reshaped chitosan film (GRCF) and sodium hyalurate (SH) on the bacteritic peritoneal adhesion in rats. Methods80 Sprague-Dawley rats were randomly divided into four groups respectively: pseudo-operation group (Group A), bacteritic infection-control group (Group B), GRCF group(Group C) and SH group(Group D). The bacteritic peritoneal adhesive model was made in the caecums of vermiform processes of the rats, and the polluted surfaces were correspondingly treated with GRCF in Group C and SH in Group D. After two and four weeks of the treatments, the abdominal cavities were reopened and the adhesive severity was evaluated according to the Bhatia's method. The caecums of vermiform processes were resected for hydroxyproline (OHP) level detection and pathological examination. ResultsAfter two and four weeks, the adhesions were significantly lighter(P=0.000) and the OHP levels were significantly lower(P=0.000) in the Group C than those in the Group B, but there was no significant difference between the Group D and B(P0.05). Pathological changes: In the Group B, the main pathological changes were acute suppurative inflammation after two weeks, and chronic inflammation with hyperblastosis of granulation and fibroplasias after four weeks. The types of pathological changes were similar in the Group C and D to those in the Group B, but degree of the pathological changes was lighter in the Group C than that in the Group B. There was no significant difference between degree of the pathological changes in the Group D and that in the Group B. ConclusionGRCF is much effective on preventing bacteritic peritoneal adhesion, however, the preventive effect of SH is not obvious." @default.
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- W2393068605 date "2005-01-01" @default.
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- W2393068605 title "Comparative study on the preventive effects of gelatinizedly-reshaped chitosan film on the bacteritic peritoneal adhesion" @default.
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