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- W2393070867 abstract "Aim To investigate the role and mechanism of tert-butylhydroquinone(tBHQ) on lipoppolysacchride(LPS)-induced impairment of human umbilial vein endothelial cell(HUVEC).Methods Before treated with LPS,HUVEC were cultured with tBHQ in vitro.MTT analysis measured the effects of LPS and tBHQ on HUVEC;Western blot analysis measured the effects of tBHQ on the levels of Nrf2 in HUVEC;DCFH-DA measured the effects of tBHQ on the levels of ROS;Western blot and ELISA analysis measured the effects of tBHQ on the levels of TNF-α,IL-1β and IL-6.Results Compared with control group,viabilities of HUVEC were decreased significantly by LPS(P0.05).However,the effects of LPS could be attenuated notably by tBHQ(P0.05).Pretreatment with tBHQ could increase the expression of nuclear Nrf2 protein significantly(P0.05),and reduce the levels of ROS,TNF-α,IL-1β and IL-6(P0.05).Conclusions To prevent LPS-induced impairment of HUVEC,tBHQ can decrease the levels of ROS inflammatory factors induced by LPS via inducing translocation of Nrf2." @default.
- W2393070867 created "2016-06-24" @default.
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- W2393070867 date "2011-01-01" @default.
- W2393070867 modified "2023-09-24" @default.
- W2393070867 title "Effects of tBHQ on Lipoppolysacchride-Induced Impairment of Human Umbilial Vein Endothelial Cell by Nuclear Factor-Erythroid 2 p45-Related Factor 2" @default.
- W2393070867 hasPublicationYear "2011" @default.
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