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- W2393074944 abstract "Objective To study expression of differential proteins biomarkers in the serum of patients with prostate cancer and benign prostatic hyperplasia(BPH) and protein chip technique by use of surface-enhanced laser desorption ionization time-of-flight mass spectrometry(SELDI-TOF-MS),and then to explore the relationship of expression of the biomarkers to the grade of pathology and clinical stage.Methods The protein expression spectrum of serums from forty-five prostate cancer and forty-five benign prostatic hyperplasia(BPH) patients were detected by SELDI-TOF-MS and protein chip technique.The data of the spectra were analyzed by software Biomarker Wizard.Results Compared with the spectra of BPH patients,there were 9 potential markers detected in untreated prostate cancer patients,the protein expression levels were high in 7 of them and low in 2 of them.Combining two biomarkers(m/z 3771 and m/z 4481) test achieved 86.5% sensitivity and 89.2% specificity in diagnosis of prostate cancer.There was statistical difference of expression of different serum biomarkers among different grades of pathology.There was no statistical difference of expression of different serum biomarkers between early stage and advanced stage.Conclusions SELDI-TOF-MS shows great potentiality for early diagnosis of prostate cancer and screening tumor biomarkers.Combining several biomarkers to detect prostate cancer can improve sensitivity and specificity.There was statistical difference of expression of different serum biomarkers among different grades of pathology,which have a close relationship with differentiation of tumor.Detecting differential proteins can help to diagnose prostate cancer,judge prognosis and guide treatment." @default.
- W2393074944 created "2016-06-24" @default.
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- W2393074944 date "2010-01-01" @default.
- W2393074944 modified "2023-09-23" @default.
- W2393074944 title "The study on differential proteins of prostate cancer and their clinical significance" @default.
- W2393074944 hasPublicationYear "2010" @default.
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