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- W2393077419 abstract "A randomized single-dose cross-over design was used to evaluate the bioequivalence of levodopa and benserazide hydrochloride capsules(test preparation) and the tablets(reference preparation,Madopar~(?)) in six Beagle dogs.The drug concentration of levodopa in plasma was determined by HPLC-MS.The main pharmacokinetic parameters of test and reference preparations were as follows:t_(max)(0.41±0.09) and(0.49±0.20) h,c_(max)(39.00±6.00) and(39.96±8.63)μg/ml,t_(1/2)(0.59±0.08) and(0.62±0.09) h,AUC_(0-t)(51.29±11.60) and(49.13±14.95)μg·h·ml~(-1),AUC_(0-∞)(51.36±11.61) and(49.21±14.95)μg·h·ml~(-1).The relative bioavailability of levodopa in test preparation was(109.13±27.50)%. The results showed that these two preparations were bioequivalent." @default.
- W2393077419 created "2016-06-24" @default.
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- W2393077419 date "2011-01-01" @default.
- W2393077419 modified "2023-09-25" @default.
- W2393077419 title "Bioequivalence of Levodopa and Benserazide Hydrochloride Capsules in Beagle Dogs" @default.
- W2393077419 hasPublicationYear "2011" @default.
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