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- W2393080698 abstract "Objective To investigate the transfection and expression of PD-L1-AAV2-RFP after rat liver transplantation. Methods All rats were divided into isogenic liver transplantation group (ISO group),liver transplantation group infected by AAV2-RFP (AAV group) and PD-L1-AAV2-RFP (PD-L1 group). Recombinant virus were respectively injected into portal vein and kept for 2 hours to transfect grafts during cold preservation in vitro. Three rats were killed on postoperative day 7 and 14 respectively. Serum samples were collected for decting liver function. Transgene expression of PD-L1 was assessed by means of fluorescent microscope and immunohistochemistry. Results Serum levels of ALT and AST increased obviously on the 7th day after transplantation,then gradually returned back to normal with time. The liver function of PD-L1 group was similar to those of ISO and AAV groups. Otherwise,the expression of RFP in PD-L1 group was significant higher than those of ISO and AAV groups observed by fluorescent microscope. The expression of PD-L1 protein was up-regulated in the liver of donor after transfection in PD-L1 group,but still lower in other groups. Conclusion During cold preservation in vitro through portal vein injection to donor liver,AAV mediated gene transfection can successfully achieve local gene expression." @default.
- W2393080698 created "2016-06-24" @default.
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- W2393080698 date "2008-01-01" @default.
- W2393080698 modified "2023-09-23" @default.
- W2393080698 title "Expression of PD-L1 gene mediated by recombinant adeno-associated virus 2 in rat liver allograft" @default.
- W2393080698 hasPublicationYear "2008" @default.
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