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- W2393084994 abstract "Objective: To assess the feasibility of chitosan scaffold as the carrier for controlled release of recombinant human bone morphogenetic protein-2(rhBMP-2) and evaluate the release kinetics of rhBMP-2 through in vitro release test. Methods: The chitosan scaffolds with rhBMP-2 sustained release system were made by emulsion freeze-dried method, and were compared with the empty chitosan scaffolds as control group. The samples were observed with scanning electron microscope. The samples were immerged into phosphate buffer solution(PBS).The released rhBMP-2 content from the samples was dynamically observed using high performance liquid chromatography at various set times. The curve of cumulative rhBMP-2 release kinetics was designed. Results: The surface and section of the scaffold was loose, multipore and sponginess. An initial burst release (33.2%) of the incorporated rhBMP-2 was observed during the first day; rhBMP-2 had been released rapidly during the 2nd to 7th day; released slowly during the 8th to 14th day; followed by a sustained release for the 15th to 30th day, which reached 81.3% at the 30th day. Conclusion: It can be concluded that the loose chitosan showed its characteristics as a sustained delivery system for rhBMP-2 and may be used as a sustained release carrier for rhBMP-2. It provided initial elements for rhBMP-2 continually inducing bone formation in bone tissue engineering." @default.
- W2393084994 created "2016-06-24" @default.
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- W2393084994 date "2006-01-01" @default.
- W2393084994 modified "2023-09-27" @default.
- W2393084994 title "In Vitro Experimental Study on Chitosan as Carrier for Sustained Release of Recombinant Human Bone Morphogenetic Protein-2" @default.
- W2393084994 hasPublicationYear "2006" @default.
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