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- W2393085318 abstract "Objective:To design and synthesize 1,2,3,4-tetrahydroisoquinolines and to determine its inhibition effect on monoamine oxidase(MAO).Methods:1-aminomethyl-1,2,3,4-tetrahydroisoquinoline was synthesized from phenylethylamine via acylation,amination with phthalimide potassium,bisehler-napieralski cyclization,hydrazinolysis and reduction reaction.Then the title compounds were synthesized.Results:Four compounds with tetrahydroisoquinoline moiety were synthesized and their structures were confirmed by infrared spectroscopy,nuclear magnetic resonance spectroscopy and mass spectrometry.Pharmacological test in vitro showed that all the five compounds had certain MAO inhibitory activity,and compound(5~7) displayed preferable selective inhibition on MAO-A.Conclusion:The obtained compounds(5~7) need further study." @default.
- W2393085318 created "2016-06-24" @default.
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- W2393085318 date "2013-01-01" @default.
- W2393085318 modified "2023-09-26" @default.
- W2393085318 title "Study on synthesis of tetrahydroisoquinolines and monoamine oxidase inhibitory activity" @default.
- W2393085318 hasPublicationYear "2013" @default.
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