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- W2393086284 abstract "Objective To explore electroencephalogram(EEG) turnover and therapeutic effect of methylprednisolone pulse therapy on epilepsy combined with electrical status epilepticus during sleep(ESES) in children.Methods Twenty-one children with epilepsy who were confirmed with ESES by active electroencephalograph(AEEG) or video electroencephalograph(VEEG),and they had seizures and reversional psychomotor development.The degree of clinical seizure was appraised and EEG after received methylprednisolone pulse therapy.The method was intravenously guttaed methylprednisolone 3 days[15-30 mg/(kg·d)],then taked out of service 4 days,which was repeated 3 times,then oraled prednisone[1.5-2.0 mg/(kg·d)],which was decrement after 4-12 weeks,the course of treatment was 3-6 months.Results Sixteen cases had effectiveness(11 cases had no seizure and 5 cases decreased above 50%),5 cases had no effectiveness(2 cases decreased under 50%,2 cases had no change,1 case aggravated).The effective power was 76.2%.The cognitive and language function of 14 cases were improved,and no severe adverse effects were found.The EEG of 15 cases were obviously improved[the index of discharge in nonrapid eye movements(NREM) less than 50% and 70% on 11 cases and 4 cases],5 cases had no improved.Fifteen cases were followed up 4-34 (9.1±1.3)months,7 cases had no seizure and ESES,the seizures of 5 cases decreased and the index of discharge in NREM less than 70%,3 cases relapsed.Conclusion Methylprednisolone pulse therapy can alleviate the symptoms and suppress ESES in children with epilepsy,thus which can improve cognitive and language function." @default.
- W2393086284 created "2016-06-24" @default.
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- W2393086284 date "2009-01-01" @default.
- W2393086284 modified "2023-09-26" @default.
- W2393086284 title "Follow-Up Study on Methylprednisolone Pulse Therapy on Epilepsy Combined with Electrical Status Epilepticus during Sleep in Children" @default.
- W2393086284 hasPublicationYear "2009" @default.
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