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- W2393087449 abstract "Objective:Study the mechanism of the clinical Chinese herbal formula which can regulate the blood lipid levels effectively.Methods:In order to made hyperlipidemic rats model,we feed the rats on the high fat for 4 weeks.We tested rat serum lipids,high-density lipoprotein receptor SR-BI and low-density lipoprotein receptor LDL-R gene and protein expression of liver cells,oxidized low-density lipoprotein receptor CD36 protein expression in kidney tissues after 4 weeks,and compared with atorvastatin groupResults:Chinese herbal formula group can significantly reduce TC,TG,LDL-C levels in hyperlipidemia rats,and there is no significant difference with the atorvastatin group(P0.05);Chinese herbal formula group can significantly increase HDL-C level of hyperlipidemia rats,with significantly difference to atorvastatin group(P0.05);Chinese herbal formula group and atorvastatin group can both turn down high-density lipoprotein receptor SR-BI gene expression and protein expression in hyperlipidemia rats liver cells,increase low-density high-fat rat liver cells lipoprotein receptor protein expression in hyperlipidemia rats liver cells,and inhibit oxidized low-density lipoprotein receptor CD36 protein expression in hyperlipidemia rats kidney tissue.Conclusion:Chinese herbal formula can regulate the blood lipid levels,and can affect the lipoprotein receptor gene and protein expression level,and play a multi-level,multi-link,multi-target regulation effect in the prevention and treatment of dyslipidemia and atherosclerosis,which is important." @default.
- W2393087449 created "2016-06-24" @default.
- W2393087449 creator A5011484028 @default.
- W2393087449 date "2010-01-01" @default.
- W2393087449 modified "2023-09-23" @default.
- W2393087449 title "The Impact of Chinese Herbal Formula to the Expression of the Lipoprotein Receptor of Hyperlipidemia Rats" @default.
- W2393087449 hasPublicationYear "2010" @default.
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