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- W2393088045 abstract "Objective To search sensitive, reliable and objective marker for estimating the age of wounds in traumatic brain injury, hence the time-course of neuronal apoptosis was investigated following the traumatic brain injury in a rat model. Methods The traumatic brain injury model was established using a modified Feeney method. Wistar rats were randomly divided into cortical impact injury groups, shame operated control group and normal control group. The neuronal apoptosis was observed at 1 h, 2 h, 5 h, 8 h, 12 h, 24 h, 48 h, 72 h, 5d and 7d respectively by TUNEL staining following traumatic brain injury. The shame operated control group was accomplished without cortical impact injury and the other processes the same as the cortical impact injury groups. Results 2 h after traumatic brain injury, the apoptotic cell death was observed at the injury side of cortex and ipsilateral hippocampus region. With the extension of injury time, the apoptotic cell index gradually increased and reached its apex during 48~72 h after traumatic brain injury and then gradually decreased. And the number of apoptotic cells was still significantly higher than the shame operated control group and normal control group at 7 d. Conclusions The apoptotic cell index may be helpful for estimating the age of wounds following traumatic brain injury and play an important role in forensic medicine practices." @default.
- W2393088045 created "2016-06-24" @default.
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- W2393088045 date "2012-01-01" @default.
- W2393088045 modified "2023-09-25" @default.
- W2393088045 title "The time-course study of apoptotic cell death after experimental traumatic brain injury in the rat" @default.
- W2393088045 hasPublicationYear "2012" @default.
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