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- W2393095182 abstract "Objective:To investigate the effect of growth hormone(GH) on gut barrier dysfunction in acute necrotizing pancreaitis(ANP) rats.Methods:ANP rats were induced by retrograde infusion of 3.5% sodium taurocholate into biliary pancreatic duct. The rats were divided into 4 groups: normal(N),sham operation(SO),ANP group and treatment(ANP+GH) group. 24 hours after operation,gut permeability was studied by level of plasma D lactate and histopathological alternation;serum GH,insulin like growth factor 1(IGF 1) and albumin were measured.Results:The gut permeability of ANP rats was increased together with decreased serum GH,IGF 1 and albumin;GH administration could relieve ANP gut histopathological changes,decrease plasma D lactate and increase serum GH and albumin level while there was no effect on serum IGF 1.Conclusion:Exogenous GH can cure ANP associated gut injury through increase of serum GH and albumin." @default.
- W2393095182 created "2016-06-24" @default.
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- W2393095182 date "2002-01-01" @default.
- W2393095182 modified "2023-09-25" @default.
- W2393095182 title "The curative effect of growth hormone on acute necrotizing pancreatitis induced gut barrier dysfunction in rats" @default.
- W2393095182 hasPublicationYear "2002" @default.
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