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- W2393098587 abstract "Objective: Investigate the relationship with clinicopathological features of the Related protein of EMT,analyze their role in NSCLC development and evaluate the correlation of their expression,and finally provide theoretical basis for clinical therapy of NSCLC.Methods: To detect the expression of the Related protein of EMT,E-cad、β-cat and N-cad、FN、Vimentin in NSCLC through immunohistochemical detection,analysis of the above expression with lung cancer clinical pathological features and their relationship.Results:(1) The positive expression rates of E-cad、β-cat and N-cad、FN、Vimentin protein in NSCLC were 50.5%(49 /97) 、28.9%(28 /97) 、8.2%(8 /97) 、34.0%(33 / 97) and 67.0%(65 /97) respectively.(2) There was significant difference of expression rates of E-cad in the histological differentiation and lymph node metastases(P 0.05).β-cat was significant difference of expression rates in the histological differentiation(P 0.05).Vimentin was significant difference of expression rates in the lymph node metastases(P0.05).FN was significant difference of expression rates in the tumor size、the histological differentiation and lymph node metastases(P 0.05).(3) In NSCLC,There was a positive correlation between the expression of E-cad and β-cat.(4) In NSCLC,VIM was a negative correlation with the expression of E-cad and β-cat.。There was a nagative correlation between the expression of FN and E-cad.(5) N-cadherin positive expression rate in NSCLC was 8.2%(8 /97),the grouping of the histological type and lymph node metastasis-positive expression were significantly different(P 0.05).Conclusion: IN SNSCLC E-cad、β-cat genes were down-regulated,especially β-catenin expression rate decreased significantly;N-cadherin,FN,VIM expression was elevated,indicating there exists the EMT phenomenon in NSCLC,indicating there exists the EMT phenomenon in NSCLC,and was related to invasion and metastasis." @default.
- W2393098587 created "2016-06-24" @default.
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- W2393098587 date "2013-01-01" @default.
- W2393098587 modified "2023-09-25" @default.
- W2393098587 title "THE STUDY OF EPITHELIAL-MESENCHYMAL TRANSITION IN NON-SMALL CELL LUNG CANCER" @default.
- W2393098587 hasPublicationYear "2013" @default.
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