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- W2393099080 abstract "Signal transduction pathways of luteinizing hormone(LH) were evaluated to manifest the mechanism of LH in promoting proliferation of cultured external theca cells from chicken prehierarchical small yellow follicles.Theca cells were challenged with LH(0.1-100 μg/L),protein kinase A(PKA) activator forskolin(FRSK,0.1-10 μmol/L) or inhibitor H89(0.01-1 μmol/L),protein kinase C(PKC) activator phorbol-12-myristate-13-acetate(PMA,0.1-10 nmol/L) or inhibitor H7(0.01-1 μmol/L) for 36 h and the proliferation of cells was determined.Results indicated that LH and FRSK stimulated the proliferation of theca cells and the LH-stimulated effect could be prevented by H89.However,PMA displayed no significant effect on cell proliferation and blockade of PKC by H7 couldn′t attenuate the LH-stimulated effect.These results suggested that LH may stimulate the proliferation of prehierarchical follicular external theca cells mainly through PKA signaling pathway." @default.
- W2393099080 created "2016-06-24" @default.
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- W2393099080 date "2008-01-01" @default.
- W2393099080 modified "2023-09-28" @default.
- W2393099080 title "Signal transduction of luteinizing hormone in stimulating proliferation of cultured theca cells from chicken small yellow follicles" @default.
- W2393099080 hasPublicationYear "2008" @default.
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