Matches in SemOpenAlex for { <https://semopenalex.org/work/W2393109722> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2393109722 abstract "BACKGROUND:Researches find that Alzheimer disease(AD) may relate with the pathological gene in chromosome;However,the relationship between Apolipoprotein E(ApoE) gene that located on No.19 chromosome and the onset of AD and vascular dementia (VD) is still not clear. OBJECTIVE:To evaluate the relationship between ApoEe4 gene and AD and VD for the discussion of its application merits in the evaluation of prognosis. DESIGN:A non-randomised and controlled study based on diagnosis. SETTING and PARTICIPANTS:A total of 1 560 ageing patients from the outpatient Department of Dysmnesia of BROCA Hospital (Paris, France) were selected from January 1996 to December 2000. All cases were Caucasians,which were divided into three groups:non-dementia group(n=845,patients with normal cognitive function or mild cognitive dysfunction),AD group(n=618) and VD group(n=97). MAIN OUTCOME MEASURES:The detective rate of ApoE alleles of each group, analysis of the independent risk factors of AD and VD. RESULTS:A total of 309 cases in AD group(50%) carried E4 alleles,which was significantly different from that of 240 cases in non-dementia group(P 0.01). Multiple factors were analysed by regression analysis with the results of that ApoEe4, age and female are the independent risk factors of AD; However, ApoEe4 is not the independent risk factor of VD (P=0.69). CONCLUSION:ApoEe4 significantly correlates with AD, which is an important risk factor of AD genesis; However, the relationship between ApoEe4 with VD is still unclear." @default.
- W2393109722 created "2016-06-24" @default.
- W2393109722 creator A5009579550 @default.
- W2393109722 date "2004-01-01" @default.
- W2393109722 modified "2023-09-23" @default.
- W2393109722 title "Relationship of the polymorphism of Apolipoprotein E gene with Alzheimer disease and vascular dementia" @default.
- W2393109722 hasPublicationYear "2004" @default.
- W2393109722 type Work @default.
- W2393109722 sameAs 2393109722 @default.
- W2393109722 citedByCount "0" @default.
- W2393109722 crossrefType "journal-article" @default.
- W2393109722 hasAuthorship W2393109722A5009579550 @default.
- W2393109722 hasConcept C104317684 @default.
- W2393109722 hasConcept C126322002 @default.
- W2393109722 hasConcept C143998085 @default.
- W2393109722 hasConcept C180754005 @default.
- W2393109722 hasConcept C207886595 @default.
- W2393109722 hasConcept C2777952318 @default.
- W2393109722 hasConcept C2779134260 @default.
- W2393109722 hasConcept C2779483572 @default.
- W2393109722 hasConcept C2984863031 @default.
- W2393109722 hasConcept C50440223 @default.
- W2393109722 hasConcept C54355233 @default.
- W2393109722 hasConcept C57089818 @default.
- W2393109722 hasConcept C71924100 @default.
- W2393109722 hasConcept C86803240 @default.
- W2393109722 hasConceptScore W2393109722C104317684 @default.
- W2393109722 hasConceptScore W2393109722C126322002 @default.
- W2393109722 hasConceptScore W2393109722C143998085 @default.
- W2393109722 hasConceptScore W2393109722C180754005 @default.
- W2393109722 hasConceptScore W2393109722C207886595 @default.
- W2393109722 hasConceptScore W2393109722C2777952318 @default.
- W2393109722 hasConceptScore W2393109722C2779134260 @default.
- W2393109722 hasConceptScore W2393109722C2779483572 @default.
- W2393109722 hasConceptScore W2393109722C2984863031 @default.
- W2393109722 hasConceptScore W2393109722C50440223 @default.
- W2393109722 hasConceptScore W2393109722C54355233 @default.
- W2393109722 hasConceptScore W2393109722C57089818 @default.
- W2393109722 hasConceptScore W2393109722C71924100 @default.
- W2393109722 hasConceptScore W2393109722C86803240 @default.
- W2393109722 hasLocation W23931097221 @default.
- W2393109722 hasOpenAccess W2393109722 @default.
- W2393109722 hasPrimaryLocation W23931097221 @default.
- W2393109722 hasRelatedWork W1983759138 @default.
- W2393109722 hasRelatedWork W2006437426 @default.
- W2393109722 hasRelatedWork W2181635086 @default.
- W2393109722 hasRelatedWork W2199280432 @default.
- W2393109722 hasRelatedWork W2289507061 @default.
- W2393109722 hasRelatedWork W2341376822 @default.
- W2393109722 hasRelatedWork W2349515693 @default.
- W2393109722 hasRelatedWork W2370342441 @default.
- W2393109722 hasRelatedWork W2375960876 @default.
- W2393109722 hasRelatedWork W2384606353 @default.
- W2393109722 hasRelatedWork W2387283916 @default.
- W2393109722 hasRelatedWork W2388890858 @default.
- W2393109722 hasRelatedWork W2389271584 @default.
- W2393109722 hasRelatedWork W2412051827 @default.
- W2393109722 hasRelatedWork W2414292604 @default.
- W2393109722 hasRelatedWork W2889714721 @default.
- W2393109722 hasRelatedWork W2980648146 @default.
- W2393109722 hasRelatedWork W3080612738 @default.
- W2393109722 hasRelatedWork W3124184754 @default.
- W2393109722 hasRelatedWork W2136207594 @default.
- W2393109722 isParatext "false" @default.
- W2393109722 isRetracted "false" @default.
- W2393109722 magId "2393109722" @default.
- W2393109722 workType "article" @default.