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- W2393128141 abstract "Objective To investigate the effect of L-arginine on cell apoptosis caused by renal ischemia reperfusion injury (RIRI) in rats.Methods The rat model of RIRI was induced by bilateral clamping the renal artery and vein for 45 minutes followed by reperfusion.Serum creatinine (Scr) and urea N-Acety-P-beta Glucosaminidase (UNAG) were measured to evaluate renal function.Nitric oxide (NO),malondialdehyde (MDA) and renal histological changes were tested to observe the degree of renal injury.Flow cytometer was used to estimate the apoptosis rate of renal cortex cells.Results The contents of Scr,MDA and UNAG significant increased in RIRI rats (P0.01),and serum NO levels were also increased in RIRI rats,but there was no significantly difference,as compared with those in sham operation group;the apoptosis rate of cell in renal cortex was obviously increased in RIRI rats (P0.01).L-arginine significantly decreased the contents of Scr,MDA,UNAG and L-arginine also could mitigated the apoptosis rate of renal cortex cells in early reperfusion and could attenuate the renal histological injury in RIRI rats.Conclusion L-arginine has protective effect against renal dysfunction in RIRI rats by increasing the levels of NO and by inhibiting the apoptosis of the renal cortex cells." @default.
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- W2393128141 date "2006-01-01" @default.
- W2393128141 modified "2023-09-23" @default.
- W2393128141 title "The effect of L-arginine on cell apoptosis caused by renal ischemia reperfusion injury in rats" @default.
- W2393128141 hasPublicationYear "2006" @default.
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