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- W2393148973 abstract "Objective To explore the relationship between cytotoxin associated protein (CagA) of Helicobacter pylori and the severity of inflammation and the density of Helicobacter pylon colonization in antral mucosa in children. Methods The serum CagA antibody was measured by the immune blotting method in 79 children with Helicobacter pylori-related chronic gastritis and detected by en-doscopy; antral mucosal biopsy specimens were obtained and processed by HE and Giemsa stain to identify the severity of inflammation and the density of Helicobacter pyloric colonization. Results There were 67 cases with positive CagA antibody in 79 children, the detection rate of CagA antibody was 84.81 % , in which 9 cases with antral mucosal mild inflammation and 58 cases with antral mucosal moderate-severe inflammation. However, in the CagA antibody negative group, there were 7 cases with antral mucosal mild inflammation and 5 cases with antral mucosal moderate-severe inflammation. The difference was statistically significant between two groups (x2= 10 076 P = 0.002), but there was no significant difference in the Helicobacter pylori colonization density between two groups (H = 0 246 P = 0 884). Conclusions The severity of antral mucosal inflammation correlated with CagA, but not with the Helicobacter pylori colonization density in Helicobacter pylori-related chronic gastritis in children. The strains of Helicobacter pylori with positive CagA may cause more severe inflammation in antral mucousa." @default.
- W2393148973 created "2016-06-24" @default.
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- W2393148973 date "2005-01-01" @default.
- W2393148973 modified "2023-09-23" @default.
- W2393148973 title "Relationship between Cytotoxin Associated Protein of Helicobacter Pylori and Severity of Inflammation and Den-sitv of Bacterial Colonization in Antral Mucosa in Children" @default.
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