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- W2393153721 abstract "OBJECTIVE: To develop a HPLC method for the content determination of cytochrome P450 3A4 (CYP3A4) probe substrate testosterone in rat liver microsomes. METHODS: The determination was performed on Ultimate-XB C18 column with mobile phase consisted of water-acetonitrile (50 ∶ 50, V/V) using diazepam as internal standard at flow rate of 1.0 mL·min-1. The detection wavelength was set at 245 nm and the column temperature was 30 ℃. The injection volume was 20 μL. RESULTS: The liner range of testosterone was 10.0～200.0 μmol·L-1 (r=0.999 5); The average method recovery rates of testosterone with low, medium and high concentration were 86.15%, 103.10% and 97.48%. The average relative recovery rates of three concentrations were 111.15%, 107.24% and 100.78%.The intra-day RSD were 3.92%, 2.46% and 2.82% and the inter-day RSD were 2.98%, 1.34% and 2.41%, respectively. CONCLUSION: The method is simple, convenient, sensitive and reproducible for the determination of CYP3A4 activity and other fields." @default.
- W2393153721 created "2016-06-24" @default.
- W2393153721 creator A5038500441 @default.
- W2393153721 date "2010-01-01" @default.
- W2393153721 modified "2023-09-25" @default.
- W2393153721 title "Content Determination of Testosterone in Rat Liver Microsomes by HPLC" @default.
- W2393153721 hasPublicationYear "2010" @default.
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