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- W2393156368 abstract "ObjectiveTo investigate the effect of calcium signal on the proliferation of cultured vascular smooth muscle cells(VSMC) of rat.Methods ~ 3H-Leucine(~ 3H-Leu) and ~ 3H-Thymidine(~ 3H-TdR) incorporation in cultured VSMC with different concentration(1 nmol/L-1 μmol/L) of ryanodine(RY) was served as markers to evaluate its proliferation and protein synthesis effect.Various inhibitors of the components of signal pathway were used to study the significance of different signal transduction pathway.ResultsRY promoted intracellular Ca~ 2+ concentration in dose dependent manner and enhanced synthesis rate of protein and nucleic acid in VSMC (P0.01).Nicardipine, H7, W7 and PD98059, which are inhibitors of calcium channel, PKC, CaM-PK and MAPK respectively, blunted the effects of RY.ConclusionIncreases in intracellular free calcium concentration augmented the proliferation of VSMC.RY induced increases in i were inhibited by various antagonists of different signal transduction pathways." @default.
- W2393156368 created "2016-06-24" @default.
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- W2393156368 date "2005-01-01" @default.
- W2393156368 modified "2023-09-24" @default.
- W2393156368 title "The Change of Calcium Signal Regulated the Proliferation of Vascular Smooth Muscle Cells from Rats" @default.
- W2393156368 hasPublicationYear "2005" @default.
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