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- W2393156784 abstract "Objective To further explore BHLHB2 related molecular biology functions,which was proved to be a novel and independent prognostic marker in pancreatic ductal adenocarcinoma.Methods Knock-down of BHLHB2 in pancreatic cancer cell line-SU86.86 was achieved by siRNA treatment.Migration essay was performed to research the relationship between BHLHB2 and cell migration.The proliferation assay induced by ACT-D to explore BHLHB2 roles in cell apoptosis.Relationship between BHLHB2 and EMT was analyzed using Western blot.Results BHLHB2 silencing with RNAi significantly promote cell migrate,and induced cell apoptosis by Actinomycin D(ACT-D)(10 μg/L,increased 1.32 fold,P0.05;100 μg/L,increased 1.41 fold,P0.05).By Western blot,BHLHB2 silencing significantly deduced E-cadherin expression(decreased 1.28 fold,P0.01),which implicated that BHLHB2 was correlated with epithelial mesenchymal transform(EMT).Conclusions BHLHB2 closely associated with cell migration,cell apoptosis and EMT in human pancreatic cancer." @default.
- W2393156784 created "2016-06-24" @default.
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- W2393156784 date "2012-01-01" @default.
- W2393156784 modified "2023-09-25" @default.
- W2393156784 title "BHLHB2 participates in cell migration,cell apoptosis and EMT in human pancreatic cancer" @default.
- W2393156784 hasPublicationYear "2012" @default.
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