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- W2393156912 abstract "AIM: To investigate the effects of BWYJ (naftopidil’s ramif ic ation) on the vascular activities in rabbits and to explore its vasodilative mec hanisms. METHODS: The isotonic contractions of the thoracic aort a strips in rabbits were recorded, and the effects of BWYJ on the concentration -response curves of noradrenaline (NA), high potassium and 5-hydroxytryptamine (5-HT) was observed. The procedure of Ca 2+ free-Ca 2+ addition was designed to indirectly observe the effects of BWYJ on intracellular free Ca 2+ ([Ca 2+] i). RESULTS: BWYJ shifted the concentratio n-response curves of NA and 5-HT to right in parallel, the maximum responses w ere unchanged, and the pA 2 values were 7.61 and 6.56, respectively. Bu t it did not affect the concentration-response curve of high potassium. In Ca 2+-free medium, BWYJ 10 -7,3×10 -7, 10 -6 and 10 -5 mol·L -1 concentration-dependently inhibited the transient contracti on induced by NA and the long-lasting contraction induced by addition of Ca 2+. But BWYJ 10 -5 mol·L -1 did not inhibit the contraction ind uced by caffeine. CONCLUSION: BWYJ may be an α-adrenergic rece ptor blocker and a 5-HT receptor blocker simultaneously. The vasodilative mech anism of BWYJ may be related to its inhibiting effects on the Ca 2+-influx and Ca 2+-release mediated by α-adrenergic and 5-HT receptors." @default.
- W2393156912 created "2016-06-24" @default.
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- W2393156912 date "2004-01-01" @default.
- W2393156912 modified "2023-09-24" @default.
- W2393156912 title "Effects of naftopidil’s ramification-BWYJ on vascular activities and it’s vasodilative mechanism" @default.
- W2393156912 hasPublicationYear "2004" @default.
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