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- W2393159669 abstract "Objective To investigate immunological function in acute phase of Henoch-Schonlein purpura(HSP) in children,in order to explore the role of immunological injury in pathogenesis of HSP.Methods Twenty children with HSP in acute phase were enrolled in this study,ten healthy children were control group.The antigen markers of T-lymphocyte,B-lymphocyte and NK cells , including CD3,CD4,CD8,CD_ 19 ,and CD_ 16/56 expression on the surface of peripheral blood lymphocytes were analyzed by flow cytometry,the serum levels of IgA,IgG,IgM and the C_3,C_4 were detected by immunol nephelometer.Results 1.CD3 + and CD4 + cell,ratio of CD4 +/CD8 + cell in HSP group were significantly lower than those in control group( P 0.001, P 0.01, P 0.05),CD_ 19 + cell was significantly higher than that in control group( P 0.05),CD8 + cell and CD_ 16 +/CD_ 56 + cell were not significantly difference between HSP and control group( P 0.05). 2.The serum concentration of IgA,IgM and C_3 in HSP group were significantly higher than those in control group( P 0.001, P 0.05, P 0.05).The level of IgG in HSP group was significantly lower than that in control group( P 0.001),the level of C_4 was no significantly difference between two groups( P 0.05).Conclusion Our study showed that there are abnormal changes in humoral immunity and cell mediated immunity in acute phase of HSP,the decrease of T-lymphocyte and increase of B-lymphocyte may be involved in the pathogenesis of HSP." @default.
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- W2393159669 date "2005-01-01" @default.
- W2393159669 modified "2023-09-24" @default.
- W2393159669 title "Study on Immunological Function in Acute Phase of Henoch-Schonlein Purpura in Children" @default.
- W2393159669 hasPublicationYear "2005" @default.
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