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- W2393174429 abstract "Objective To study the state of oxidative stress induced by sodium arsenite (NaAsO2) in Chang liver cells. Methods MTT assay was used to evaluate the viability of Chang liver exposed to NaAsO2(0,0.1,1,5,10,20,30,50,80,100,200 μmol/L). The level of ROS was detected by staining cells with DCFH-DA. The activity of SOD and the content of MDA were determined by xanthine oxidase and thiobarbituric acid methods respectively. Results The viability of Chang liver increased as treated with NaAsO2 at dose of 0.1 μmol/L,but decreased at doses of over 1 μmol/L. Compared with the control group,the level of ROS and the content of MDA were significantly elevated (P0.05),while the activity of SOD was significantly decreased (P0.001). Conclusion Oxidative stress may be an important mechanism for the toxicity of sodium arsenite to Chang liver cells." @default.
- W2393174429 created "2016-06-24" @default.
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- W2393174429 date "2008-01-01" @default.
- W2393174429 modified "2023-09-24" @default.
- W2393174429 title "Oxidative Stress Induced by NaAsO_2 in Chang liver Cells" @default.
- W2393174429 hasPublicationYear "2008" @default.
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