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- W2393190954 abstract "OBJECTIVE To study the excretion rule in urine of NM394,a type of prulifloxacin's Active Metabolite in human body,after single and multiple-times orally taking prulifloxacin tablet 200mg in health volunteers.METHODS 8 healthy vol- unteers were chosen,200mg Prulifloxacin tablets were taken according to experimental design and their urine samples were collected in required periods.HPLC methods for NM394 concentration determination in urine also were established.and phar- macokinetics parameters were calculated by DAS software.RESULTS The average excretion rate of prulifloxacin's Active Metabolites NM394 was(45.8±20.0)% and the total amounts of it was(69.2±30.2)mg when it was taken 200 mg once in 48 h.k was(0.104±0.015)h~(-1),t_(1/2)was(7.5±1.1)h.Similarly,Its parameters,k,t_(1/2)and excretion amount in 48 h after tak- ing 200 mg finally in stable state was(0.094±0.013)h~(-1),(7.5±1.1)h and(77.4±27.4)mg.CONCLUSION Pharmacoki- netics parameters of NM394 when single and multiple doses orally taken prulifloxacin tablets(200 mg)have no significant change.This shows that prulifloxacin can not be accumulated in the body in this dose.Also it is found that NM394 concentra- tion in urine is much higher than plasma.This reminds that prulifloxacin has better curative effect for urethritis which is infec- ted by sensitive bacteria," @default.
- W2393190954 created "2016-06-24" @default.
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- W2393190954 date "2008-01-01" @default.
- W2393190954 modified "2023-09-25" @default.
- W2393190954 title "Pharmacokinetics of prulifloxacin tablets in healthy volunteers'urine" @default.
- W2393190954 hasPublicationYear "2008" @default.
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