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- W2393201717 abstract "Objective To investigate the pathological regression of the coagulative necrosis ofliver tissues following high intensity focused ultrasound (HIFU) sonication. Methods The GL-1 typeHIFU therapeutic apparatus was used to carry out localized lesions on the liver tissues in 28 mini swinewith a working frequency of 1. 6 MHz, intensity of 13153 W/cm2, and duration of 3 s. After autopsy,the morphology of the target lesions were observed immediately after the sonication and on the 3 rd, 7th, 14 th, 21 st, and 28 th day following the treatment. Results The moment after the ultrasoundtreatment the tissue structure of the liver was ruptured, the boundary of the hepatic lobules were stillvisible, and pyknotic nuclei were seen in most of the hepatic cells. Electron microscopy revealed thatthe hepatic cells in an irreversible state and nuclear fragmentation, karyolysis. Clear demarcation separating coagulative necrosis and the normal tissues were seen on the third day. Fibroplastic proliferationwas observed 14 days later. With the lengthening of time (21 days later), the coagulative necrosed tissues gradually got liquefied and absorbed and replaced by the newly grown liver tissues (28 days ). Conclusion The regressive changes caused by HIFU sonication provided significant laboratory data for theestablishment of a clinical program of tumor treatment." @default.
- W2393201717 created "2016-06-24" @default.
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- W2393201717 date "1999-01-01" @default.
- W2393201717 modified "2023-09-23" @default.
- W2393201717 title "Pathological regression following localized ablation of liver tlssues of 28 mini swine with high intensity focused ultrasound" @default.
- W2393201717 hasPublicationYear "1999" @default.
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