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- W2393224452 abstract "Objective To optimize the formulation and preparation conditions of cimetidine hollow microspheres by orthogonal test and to study the release profile of microspheres. Methods Cimetidine hollow microspheres were prepared by the solvent diffusion-evaporation method. Formulation and process factors including the encapsulation efficiency,yield and rate of floatage were fully investigated using orthogonal test to obtain microspheres with good dispersion. The dissolution experiments of the hollow microspheres prepared under the optimized conditions proceeded in vitro to analyze the mechanism of drug release behavior. Results The prepared microspheres were spherical and smooth in appearance. The particle size distribution was uniform. The drug loading and encapsulation efficiency were 19. 48% and 65. 37%,respectively. More than99% of the microspheres tended to float over simulated gastric fluid for 12 h. Conclusions This preparation method of microspheres is simple and reproducible. These microspheres show excellent floatability and continuous release performance. The accumulative release profile in vitro can be described by the Higuchi equation." @default.
- W2393224452 created "2016-06-24" @default.
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- W2393224452 date "2014-01-01" @default.
- W2393224452 modified "2023-09-26" @default.
- W2393224452 title "Orthogonal experiments for optimizing the formulation and preparation conditions of cimetidine hollow microspheres and study on the release profile of microspheres in vitro" @default.
- W2393224452 hasPublicationYear "2014" @default.
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