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- W2393235583 abstract "Objective To study the effects of matrine in combination with 5-fluorouracil (5-FU) on inhibiting transplanted gastric cancer (cell line SGC-7901) in the nude mice and their myelotoxicity effects. Methods The two dosages of matrine (50 mg/kg and 100 mg/kg) combined respectively with 50 mg/kg of 5-fluorouracil (5-FU) were injected intra-abdominally, and 50 mg/kg or 100 mg/kg matrine or 5-FU injection alone groups served as controls. The relative tumor volume (RTV) and tumor inhibition rate (IR) were calculated. The nude mice bone marrow was taken, the number of the nucleated cells were calculated, and bone marrow colony was cultured. Results The tumor-inhibiting effect in the combined group of 100 mg/kg of matrine +50 mg/kg of 5-FU was significantly increased as compared with those in all the control group ( P 0.01), and much stronger than that of 50 mg/kg of matrine+50 mg/kg of 5-FU group ( P 0.05). The effect of bone marrow suppression in combination group was not different with that in control group.Comparing with the control group, the bone marrow colony of the treatment group grew actively. Conclusions The inhibiting effect of the combined use of matrine and 5-FU on the gastric carcinoma in nude mice was significantly superior to that of separated use. The combined use had somewhat stronger inhibiting effect on bone marrow hemotopoietic cells of the nude mouse during its proliferating period rather than stationary period." @default.
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- W2393235583 date "2005-01-01" @default.
- W2393235583 modified "2023-09-25" @default.
- W2393235583 title "Synergistic suppressive effects of matrine and 5-fluorouracil on growth of implanted gastric cancer in nude mice" @default.
- W2393235583 hasPublicationYear "2005" @default.
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