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- W2393243000 abstract "For porous hollow silica nanoparticles(PHSN),drug can be loaded not only in its inner cavity and in the pores formed in its shell(drug inside,DI),but also on its external surface(drug outside,DO).Determination of DI/DO value of the drug loaded PHSN is of great importance for the study of the drug loading technology and the sustained release behaviors of the prepared formulation.This study proposed a method combining the thermal gravity(TG) analysis with the dissolution test method to evaluate the DI/DO value,in which the TG analysis could measure the total amount of loaded drug,while the DO could be obtained from the dissolution test due to the rapid release property of DO.The effects of molecular size of the loaded drug and different loading methods on DI/DO value were investigated,and it was found that the drug with smaller molecular size could be encapsulated much easier into the inner part of the nano-carrier and higher DI/DO value would be obtained.As compared with the impregnating drug loading(IDL) method,the supercritical fluids drug loading(SFDL) method can achieve the drug loaded PHSN with higher DI/DO value and better sustained release behavior.However,the operating cost of SFDL method is much higher than that of IDL method." @default.
- W2393243000 created "2016-06-24" @default.
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- W2393243000 date "2007-01-01" @default.
- W2393243000 modified "2023-09-27" @default.
- W2393243000 title "Study of Drug Loading Distribution of Porous Hollow Nano-Carriers" @default.
- W2393243000 hasPublicationYear "2007" @default.
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