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- W2393265905 abstract "Objective:The investigation and analysis of related factors of central nervous system(CNS) defects among children aged 0 to 6 years in Hebei province from January 1,2003 to December 31,2008.Methods:A detailed record of children 's birth place,date of birth,sex,parity,parental age and possible risk factors with a retrospective investigation in the whole group.Results: A total of 9498 cases with CNS defects was found in 4 611 808 children aged 0 to 6 years,and the average incidence was 21.42/10000.From the year of 2003 to 2006,the CNS defect remained higher levels in Hebei province,and the incidence were close to or higher than 21.42/10000 of the 6 years average level(P 0.01).The occurrence of CNS defect showed a downward trend from the year 2007 to 2008(P0.001).In the all cases,cerebral palsy is the largest proportion up to 64.59%,followed by congenital mental retardation,accounted for 24.59% and neural tube defects accounted for 10.45%.The analysis of 9498 cases children with CNS defect display: 934 cases of one or both parents have a genetic disease,history of familial disease accounted for 9.83%,and 2164 cases of maternal adverse factors(including viruses to microbial infection,cold,exposure to toxic and harmful substances,pollutants,medication,nutrition,adverse pregnancy history,age factors) accounted for 22.78%,331 cases of the father factor(including pollution and poisoning exposure history,genetic diseases and other related fees) accounted for 3.48%,a total of 2166 cases of birth factors(including preterm delivery,hypoxia,birth trauma,hemolysis,multiple births and so on) accounted for 22.80%,3903 cases of unexplained factors accounted for 41.09%.Conclusion;Annual prevalence of CNS defects in Hebei province presents a decling trend in this years.The effective way to reduce children born with CNS defects especially neural tube defects,cerebral palsy and mental retardation is to enhance pre-pregnancy,pregnancy health care,eugenic genetics counseling and guidance,and to improve the detection rate of high risk pregnancy." @default.
- W2393265905 created "2016-06-24" @default.
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- W2393265905 date "2012-01-01" @default.
- W2393265905 modified "2023-09-23" @default.
- W2393265905 title "The investigation and analysis of related factors of central nervous system(CNS) defects among children aged 0 to 6 years in Hebei province" @default.
- W2393265905 hasPublicationYear "2012" @default.
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