Matches in SemOpenAlex for { <https://semopenalex.org/work/W2393277844> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2393277844 endingPage "64" @default.
- W2393277844 startingPage "659" @default.
- W2393277844 abstract "17α-Methyltestosterone (Ⅰ) and related steroids were studied for their anabolic and androgenic activities in castrated rats and mice. For rats the levator ani weight was taken as the criterion of anabolic activity, and the weight of the seminal vesicles served as a measure of androgenic activity. For mice the same parameters were used and, besides, the kidney weight was employed as an additional measure of anabolic activity. Results indicated that the anabolic and androgenic activities of 17α-methyl-(5α)-androstane-17β-ol-3-one (Ⅱ) or 17α-methyl-(5α)-androstane-3β, 17β-diol (Ⅲ), 4,5-hydro-genated analogues of (Ⅰ), at a dosage of 30 mg/kg by garage in castrated rats, were not significantly different from those of Ⅰ. However, when the doses were reduced to 12.5 mg/kg, the anabolic activity of Ⅱ in castrated mice was much greater than that of Ⅰ, while the androgenic activity of the two compounds was approximately equal. The anabolic and androgenic activities.of Ⅲ were weaker as compared with those of Ⅰ.The compound 17α-methyl-(5α)-androstane-17β-ol (Ⅳ) (3-deoxy-analog of Ⅰ) at a daily dosage of 30 mg/kg by gavage in castrated rats was shown to be more active on the levator ani and the seminal vesicles than Ⅰ. In castrated mice, Ⅳ caused similar anabolic effects as Ⅰ in doses of 12.5 mg/kg, while its androgenic potency was only one third of that of Ⅰ. Castrated rats and mice were treated with 5α-androstane-3-ol and 5α-androstane-3-one (17-deoxy analogue of testosterone) by gavage or by injection at a dosage of 30 and 40 mg/kg. Neither anabolic nor androgenic activities were observed. From the above results, it may be concluded that removal of the oxygen atom from C_3 and hydrogenation at C_4 and C_5 in 17α-methyltestosterone molecule may increase anabolic and/or decrease androgenic activity, while removal of the oxygen from C_(17) of testosterone results in loss of both anabolic and androgenic activities. In view of the increase in anabolic activity by removal of the oxygen at C_3, synthesis of and pharmacological studies on a series of 3-deoxy analogues of testosterone and cortisone are in progress and will be reported in due course." @default.
- W2393277844 created "2016-06-24" @default.
- W2393277844 creator A5039867867 @default.
- W2393277844 creator A5042694068 @default.
- W2393277844 date "1964-01-01" @default.
- W2393277844 modified "2023-09-25" @default.
- W2393277844 title "[Anabolic and androgenic activities of 17-alpha-methyltestosterone and related steroids in castrated rats and mice]." @default.
- W2393277844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5900192" @default.
- W2393277844 hasPublicationYear "1964" @default.
- W2393277844 type Work @default.
- W2393277844 sameAs 2393277844 @default.
- W2393277844 citedByCount "0" @default.
- W2393277844 crossrefType "journal-article" @default.
- W2393277844 hasAuthorship W2393277844A5039867867 @default.
- W2393277844 hasAuthorship W2393277844A5042694068 @default.
- W2393277844 hasConcept C1008401 @default.
- W2393277844 hasConcept C105702510 @default.
- W2393277844 hasConcept C126322002 @default.
- W2393277844 hasConcept C134018914 @default.
- W2393277844 hasConcept C185592680 @default.
- W2393277844 hasConcept C202751555 @default.
- W2393277844 hasConcept C2777567352 @default.
- W2393277844 hasConcept C2777911890 @default.
- W2393277844 hasConcept C2778586440 @default.
- W2393277844 hasConcept C2778616789 @default.
- W2393277844 hasConcept C2779256933 @default.
- W2393277844 hasConcept C2779279991 @default.
- W2393277844 hasConcept C2781244320 @default.
- W2393277844 hasConcept C55493867 @default.
- W2393277844 hasConcept C57992300 @default.
- W2393277844 hasConcept C71315377 @default.
- W2393277844 hasConcept C71924100 @default.
- W2393277844 hasConceptScore W2393277844C1008401 @default.
- W2393277844 hasConceptScore W2393277844C105702510 @default.
- W2393277844 hasConceptScore W2393277844C126322002 @default.
- W2393277844 hasConceptScore W2393277844C134018914 @default.
- W2393277844 hasConceptScore W2393277844C185592680 @default.
- W2393277844 hasConceptScore W2393277844C202751555 @default.
- W2393277844 hasConceptScore W2393277844C2777567352 @default.
- W2393277844 hasConceptScore W2393277844C2777911890 @default.
- W2393277844 hasConceptScore W2393277844C2778586440 @default.
- W2393277844 hasConceptScore W2393277844C2778616789 @default.
- W2393277844 hasConceptScore W2393277844C2779256933 @default.
- W2393277844 hasConceptScore W2393277844C2779279991 @default.
- W2393277844 hasConceptScore W2393277844C2781244320 @default.
- W2393277844 hasConceptScore W2393277844C55493867 @default.
- W2393277844 hasConceptScore W2393277844C57992300 @default.
- W2393277844 hasConceptScore W2393277844C71315377 @default.
- W2393277844 hasConceptScore W2393277844C71924100 @default.
- W2393277844 hasIssue "10" @default.
- W2393277844 hasLocation W23932778441 @default.
- W2393277844 hasOpenAccess W2393277844 @default.
- W2393277844 hasPrimaryLocation W23932778441 @default.
- W2393277844 hasRelatedWork W122828633 @default.
- W2393277844 hasRelatedWork W1975727305 @default.
- W2393277844 hasRelatedWork W1981433740 @default.
- W2393277844 hasRelatedWork W1983501993 @default.
- W2393277844 hasRelatedWork W1993550208 @default.
- W2393277844 hasRelatedWork W2003790966 @default.
- W2393277844 hasRelatedWork W2023266651 @default.
- W2393277844 hasRelatedWork W2028984501 @default.
- W2393277844 hasRelatedWork W2063540588 @default.
- W2393277844 hasRelatedWork W1990398188 @default.
- W2393277844 hasVolume "11" @default.
- W2393277844 isParatext "false" @default.
- W2393277844 isRetracted "false" @default.
- W2393277844 magId "2393277844" @default.
- W2393277844 workType "article" @default.