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- W2393280333 abstract "Objective To study the effects of β-amyloid(Aβ25-35) on intra-cellular calcium homeostasis on SD rat hippocampus cells,thereby to investigate the mechanism of neurotoxicity of Aβ25-35.Methods A total of 30 male SD rats were randomly divided into six groups(with 10,5,1 μg Aβ25-35),which were treated with injection style of inner hippocampus with Aβ25-35,meanwhile normal group,physiological saline group and sham operated group were set up.After executed experimentation for 14 d,the activity of Ca2+-ATPase,the change of intra-cellular free calcium concentration and the expression of Sorcin and Ryr2 receptors mRNA by PCR were detected.Results Compared with physiological saline group,Ca2+-ATPase activity of Aβ25-35 group descended significantly following the increase of dose,but physiological saline group and sham operated group and normal group had no significant difference;Aβ25-35 increased significantly intracellular calcium concentration compared with that of physiological saline group(P0.05) with dose-dependent manner(P0.05),while sham operated group and normal group had no significant difference compared with physiological saline group;Meanwhile the expression of sorcin and Ryr2 receptors’ mRNA decreased after the injection of Aβ25-35,with dose dependent manner(P 0.05).No significant difference was seen among normal group,sham operated group and physiological saline group.Conclusion Aβ25-35 may have neurotoxicity effect on hippocampus cells by disturbing the calcium homeostasis." @default.
- W2393280333 created "2016-06-24" @default.
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- W2393280333 date "2012-01-01" @default.
- W2393280333 modified "2023-09-23" @default.
- W2393280333 title "Effect of β-amyloid injection on the intra-cellular calcium homeostasis of neuron in hippocampus of rats" @default.
- W2393280333 hasPublicationYear "2012" @default.
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