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- W2393285146 abstract "Vascular endothelial growth factor (VEGF - A) and lymph - vascular endothelial growth factor (VEGF - C) mRNA were examined by Northern blot in 8 normal pancreatic tissues and 8 pancreatic carcinoma specimens. The expression of VEGF A、VEGF- C protein were examined by immunohistochemical staining in 50 pancreatic carcinoma specimens. Northern blot analysis revealed the levels of the VEGF- A 、 VEGF- C transcription were approximately 3.0、3.6- fold higher in the pancreatic cancers compared with the normal pancreas. Immunohistochemical staining revealed 25 cases (50% ) were positive for VEGF - A and 40(80%) cases were positive for VEGF - C in the cytoplasm of the cancer cells in 50 pancreatic cancer cases, x2 analysis indicated that the presence of VEGF - A in the cancer cells was associated with statistically significant increase in the size and local extension of the primary tumor ( P 0.05), and that the presence of VEGF - C in the cancer cells was associated with statistically significant increase in lymph node metastasis (P 0.05). There was no correlation between the expression of VEGF - A and VEGF - C in the same cancer cells. These findings indicated that VEGF - A and VEGF - C are coexpressed in pancreatic cancers , there is no any relationship between the expression of VEGF - A and VEGF - C in pancreatic cancer and it probable lead to different biological characteristics of tumor cells." @default.
- W2393285146 created "2016-06-24" @default.
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- W2393285146 date "2004-01-01" @default.
- W2393285146 modified "2023-09-25" @default.
- W2393285146 title "Expression of vascular, lymph - vascular endothelial growth foctors in human pancreatic cancer" @default.
- W2393285146 hasPublicationYear "2004" @default.
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