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- W2393301686 abstract "Background and purpose:A chemokine receptor,CXCR4,and its endogenous ligand,stromal cell-derived factor-1(SDF-1),have been recognized to be involved in the invasion and metastasis of cancer.Inhibition of CXCR4 may be a new therapeutic target.We studied whether shRNA-CXCR4 could inhibit the CXCR4 gene expression and the proliferation in MCF-7,MDA-MB-231 and MDA-MB-435s breast cancer cells.Methods:Through knockdown CXCR4 by shRNA,the CXCR4 mRNA expression was detected by RT-PCR and the CXCR4 protein expression was mesured by Western blot.The proliferation of breast cancer cells was evaluated by MTT and flow cytometry.Results:The CXCR4mRNA and its protein expression decreased significantly in MCF-7(the average level of CXCR4 mRNA and protein expression were 0.089,0.177 in PG-CXCR4 group,compared with 0.327 and 0.313 for mRNA expression,0.911,0.874 for protein expression in control and PG-HK group),MDA-MB-231(the average level of CXCR4 mRNA and protein expression were 0.152 and 0.153 in PG-CXCR4 group,compared with 0.40 and 0.45 for mRNA expression,0.829 and 0.878 for protein expression in control and PG-HK group)and MDA-MB-435s(the average level of CXCR4 mRNA and protein expression were 0.198 and 0.173 in PG-CXCR4 group,compared with 0.69 and 0.77 for mRNA expression,0.877 and 0.906 for protein expression in control and PG-HK group)breast cancer cells(P0.05).shRNACXCR4 could inhibit the cell proliferation(P0.05)and induce the cell cycle arrest at G0/G1 phase with a significant decrease of cells in S phase(P0.05).Conclusions:Silencing CXCR4 could inhibit the breast cancer growth.It may be a potentially valuable therapeutic target in the treatment of breast cancer." @default.
- W2393301686 created "2016-06-24" @default.
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- W2393301686 date "2007-01-01" @default.
- W2393301686 modified "2023-09-23" @default.
- W2393301686 title "The effect of shRNA-CXCR4 on breast cancer cell growth and proliferation in vitro" @default.
- W2393301686 hasPublicationYear "2007" @default.
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