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- W2393313168 abstract "Objective To observe the clinical effect of Sarcandra glabra compatible granule against xerostomia induced by radiotherapy in nasopharyngeal carcinoma(NPC).Methods One hundred and twenty five patients with NPC were divided into three groups:conventional radiotherapy(CRT) group(42 cases),CRT combined with Sarcandra glabra compatible granule group(43 cases) and intensity-modulated radiation therapy(IMRT) group(40 cases).The patients in CRT combined with Sarcandra glabra compatible granule group were treated with oral Sarcandra glabra compatible granule three days before radiotherapy,4 g once for twice a day,until the end of radiotherapy.All the patients in the three groups received induction chemoradiotherapy and concurrent radiotherapy and chemotherapy,the chemotherapy regimen was PF.Salivary secretion was examined before radiotherapy,at the end of radiotherapy,at 3 months,6 months,12 months,18 months and 24 months after radiotherapy,respectively.Simultaneously,xerostomia of the patients was observed.Results There was no significant difference in salivary secretion before radiotherapy among three groups(P0.05).Salivary secretion showed significant difference at the end of radiotherapy,at 3 months,6 months,12 months,18 months and 24 months after radiotherapy among three groups(P0.05),which in CRT combined with Sarcandra glabra compatible granule group and IMRT group were obviously higher than that in CRT group(P0.05);No significant difference was found between CRT combined with Sarcandra glabra compatible granule group and IMRT group(P0.05).There was significant difference in xerostomia at the end of radiotherapy,at 3 months,6 months,12 months,18 months and 24 months after radiotherapy among three groups(P0.05).The extend of xerostomia in CRT combined with Sarcandra glabra compatible granule group and IMRT group were obviously slighter than that in CRT group(P0.05),no significant difference was found between CRT combined with Sarcandra glabra compatible granule group and IMRT group(P0.05).Conclusion Sarcandra glabra compatible granule can attenuate the severity of xerostomia induced by chemoradiotherapy.It would contribute to improvement of the function of parotid glands." @default.
- W2393313168 created "2016-06-24" @default.
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- W2393313168 date "2012-01-01" @default.
- W2393313168 modified "2023-09-24" @default.
- W2393313168 title "Clinical Observation on Sarcandra Glabra Compatible Granule in Prevention and Treatment of Xerostomia Induced by Radiation" @default.
- W2393313168 hasPublicationYear "2012" @default.
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