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- W2393313397 abstract "AIM: To examine the role of endogenous endothlin-1(ET-1) in the pathogenesis of acute ischemic arrhythmia in isolated perfused rat hearts by decreasing ET-1 expression with ET-1 mRNA cleaving 10-23 deoxyribozyme. METHODS: ET-1 10-23 deoxyribozymes were designed and synthesized. ET-1 RNA was transcribed in vitro and FAM-labeled 10-23 deoxyribozyme was used to select cleavable 10-23 deoxyribozymes in vitro and detect uptake in the myocardium. Acute ischemic arrhythmia produced by occlusion of the left anterior descending branch of coronary artery(LAD) was observed in isolated perfused rat hearts 4 h after the intravenous injection of 10-23 deoxyribozyme in intact rats. RESULTS: ET-1 10-23 deoxyribozyme efficiently cleft ET-1 RNA substrates. 4 h after the intravenous injection, wide distribution of FAM-labeled 10-23 deoxyribozyme was seen in the myocardium. The intravenous administration of ET-1 10-23 deoxyribozyme significantly reduced arrhythmia score, total ventricular premature beats, ventrical tachycardia counts and duration of ventrical tachycardia and/or ventrical fibrillation after occlusion of LAD in a dose-dependent manner, while 10-23 deoxyribozyme with reverse arms had no significant effects on acute arrhythmias. CONCLUSION: ET-1 10-23 deoxyribozyme designed in this study cleft ET-1 RNA substrate efficiently and reduced the acute ischemic arrhythmias, which shows that endogenous ET-1 plays an important role in acute ischemic arrhythmia." @default.
- W2393313397 created "2016-06-24" @default.
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- W2393313397 date "2004-01-01" @default.
- W2393313397 modified "2023-09-25" @default.
- W2393313397 title "Effects of endothelin-1 10-23 deoxyribozyme on acute ischemic arrhythmia in isolated perfused rat hearts" @default.
- W2393313397 hasPublicationYear "2004" @default.
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