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- W2393314718 abstract "OBJECTIVE:To study the bioequivalence of two candesartan cilexetil preparations in healthy subjects.METH-ODS: A single dose of Candesartan Cilexetil tablets(test preparation) or Candesartan Cilexetil capsules(control preparation) was administrated to 20 healthy male volunteers in a randomized crossover way.The concentrations of Candesartan in serum were determined by HPLC.The pharmacokinetic parameters and bioequivalence were calculated with 3p97 program.RESUL- TS:The main pharmacokinetic parameters of the test and control preparation were as follows:Cmax were (276.785±28.957)and (269.118±30.116)ng·mL-1,tmax were (4.12±0.79) and (3.93±0.87)h,t1/2 were (8.63±1.04) and(9.06±1.14)h,AUC0～48 were (2 589.248±306.674) and (2 438.946±313.259)ng·h·mL-1,AUC0～∞ were (2 613.276±309.460) and (2 493.636± 324.491)ng·h·mL-1,respectively.The relative bioavailability of the test Candesartan Cilexetil tablets was(104.80±16.48)%.CONCLUSIONS:The two Candesartan Cilexetil preparations are bioequivalent." @default.
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- W2393314718 date "2007-01-01" @default.
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- W2393314718 title "Studies on the Bioequivalence of Two Candesartan Cilexetil Preparations" @default.
- W2393314718 hasPublicationYear "2007" @default.
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