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- W2393320046 abstract "Objective To investigate the conditions of the oriented differentiation of human adult mesenchymal stem cells(MSCs) into neuron like cells in vitro . Methods MSCs were isolated from human adult bone marrow through density gradient with Ficollll paque(1.077 g/ml) and then amplified as undifferentiated cells for 10 generations. Four different groups of neural differentiation inducing conditions were selected for the induction of MSCs differentiation into neuronal cells, respectively. The expressions of neuron specific enolase(NSE), neurofilament protein(NF M) and glial fibriliary acidic protein(GFAP) were detected by immunocytochemistry. Results MSCs were induced to differentiate into cells with a typical neuronal morphology, expressing NF M and increased levels of NSE. The induced neuron like cells extended long processes and filopodia. Under an optimal differentiation condition, i.e. after treatment with ATRA, bFGF, BME and DMSO, almost 80% of the cells expressed NF M and 86% of the cells expressed intensively NSE. Conclusion MSCs can be induced to differentiate into neuron like cells with high positive rate of induced differentiation." @default.
- W2393320046 created "2016-06-24" @default.
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- W2393320046 date "2003-01-01" @default.
- W2393320046 modified "2023-09-25" @default.
- W2393320046 title "Differentiation of human adult mesenchymal stem cells into neuron-like cells in vitro" @default.
- W2393320046 hasPublicationYear "2003" @default.
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