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- W2393323010 abstract "Objective To investigate the molecular mechanism of effects of immunization with zona pellucida (ZP) antigen on ovarianfunctions. Methods: Each female Balb/c mouse received 0.1 ml of adjuvant emulsion and porcine ZP (or PBS) in two hind footpads or intracutaneously, at two weeks interval for three times. Steroid hormone and ZP antibody levels were monitored. The histopathology of ovaries andexpression of EGF, IL-1 in the ovaries were studied. Results: All immunized mice developed high titers of serum antibodies to ZP and low concentrations of serum estradiol(P 0.01 ). Moraeover, the latter correlated negatively with the former(r = - 0. 85, P = 0.001 ). There wasa noticeable reduction in Ovarian she and number of growing follicle and luteum after three immunizations. Lymphocyte infiltration in the follicles was found. Expression of IL-1 in the ovaries increased compared to controls, while that of EGF decreasing significantly. Conclusion: Theresearch suggests that the ZP antigen immunization results in increasing atresia follicles and disorders of local immune milieu in the ovaries,which facilitates depletion of follicles in different Phases and leads to premature ovarian failure." @default.
- W2393323010 created "2016-06-24" @default.
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- W2393323010 date "2000-01-01" @default.
- W2393323010 modified "2023-09-25" @default.
- W2393323010 title "Mechanism of premature ovarian failure in murine autoimmune oophoritis immunized by a porcine zona pellucida" @default.
- W2393323010 hasPublicationYear "2000" @default.
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