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- W2393323259 abstract "Objective To understand the drug resistance mutations of reverse transcriptase gene and protease gene of HIV-1 strains in some antiretroviral-treated AIDS patients in Heilongjiang province,and to provide the scientific data for clinical antiviral treatment.Methods HIV-1 RNA were extracted from AIDS patients’plasma,and partial pol gene fragments were amplified by using RT-PCR method and were sequenced.Then,the partial pol sequences were analyzed for genotypic drug resistance mutations.Results The analysis indicated that number 2 sample in 2005,number 3 sample in 2007 and number 5 sample in 2007 has one PI minor resistance mutation A71T,L10I and A71T respectively,but the mutations cant’ cause resistance to antiretroviral drugs.Number 2 sample in 2005,number 5 sample in 2007 and number 6 sample in 2007 have some mutations associated with reverse transcriptase(RT) inhibitors.For example,the mutations to NRTIs are D67N,K70R,M184V,K219Q and T215FI,the mutations to NNRTIs are K103T,Y181C,K103N,P225H,K238T,V106A and G190A.These mutations made the three samples have different levels of resistance to most of NRTIs and NNRTIs.Conclusion Among detected samples,the most were sensitive to available antiretroviral drugs,but there were three samples that had resistance to most of the RT inhibitors.That reminded us to pay more attention to the surveillance of HIV-1 drug resistance mutations in our province,and to understand the drug resistance levels among treatment-naive and antiretroviral-treated HIV/AIDS patients." @default.
- W2393323259 created "2016-06-24" @default.
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- W2393323259 date "2009-01-01" @default.
- W2393323259 modified "2023-09-23" @default.
- W2393323259 title "Analysis on Detection for Genotypic of Drug Resistance Mutations of HIV-1 Strains in Heilongjiang Province between 2004 and 2007" @default.
- W2393323259 hasPublicationYear "2009" @default.
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