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- W2393329343 abstract "OBJECTIVE: To study the pharmacokinetics of compound famotidine chewable tablets in healthy volunteers.METHODS: An open study was performed in which 10 healthy volunteers(5 males and 5 females) were assigned to receive 40mg single dose of compound famotidine chewable tablets orally.The plasma concentrations of famotidine were determined by HPLC,and the pharmacokinetic parameters were calculated with the aid of PKS software(magnsoft,shanghai).RESULTS: The main pharmacokinetic parameters of famotidine after oral single dose of 40mg compound famotidine chewable tablets were fitted one-compartment model,which were stated as follows: tmax=(2.3± 0.4) h,Cmax=(88.73± 15.07) ng· mL-1,AUC0～ 14 =(436.6± 49.6) ng· h· mL-1,AUC0～ ∞ =(562.4± 63.3) ng· h· mL-1,Ka=(0.7± 0.4) h-1,t1/2 Ka=(1.36± 0.84) h,t1/2 K=(3.8± 0.7) h,CL/F=(0.08± 0.01) mg· mL· ng-1· h-1,MRT0～ 14=(5.0± 0.3) h and MRT0～ ∞ =(9.6± 2.3) h.CONCLUSION: We concluded that the absorption and metabolism of famoidine won' t be affected by calcium carbonate and magnesium hydroxide,our result is consistent with that reported in literature." @default.
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- W2393329343 date "2007-01-01" @default.
- W2393329343 modified "2023-09-23" @default.
- W2393329343 title "Pharmacokinetics of Compound Famotidine Chewable Tablets in Healthy Volunteers" @default.
- W2393329343 hasPublicationYear "2007" @default.
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