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- W2393329462 abstract "Objective To evaluate the Alzheimer-like disease(AD)mouse model induced by D-galactose with biochemical,histological,behavior methods,and to observe the expression of galanin in the hippocampus.Methods The C57 mice were injected with D-galactose(150mg/kg,i.p.90 d)to make AD model.The Y-maze test,analysis of TChE、 ChAT、GSH-PX、SOD、MDA、MAO and other enzymes,transmission electron microscopy(TEM)observation as well as the galanin expression with immunofluorescent assay were carried out to evaluate the mouse model for AD.Results Compared with the control group,the ChAT activity in the model group decreased,cell nuclear shrank and mitochondria spoiled,the ability of learning and memory decreased evidently,high expression of galanin in the hippocampus was detected with immunofluorescent assay.Conclusions The mouse model for AD induced by D-galactose simulated some characteristics of human AD to some extent and can be used as an approving animal model to study AD.Galanin expression in the hippocampus of the model group increased evidently." @default.
- W2393329462 created "2016-06-24" @default.
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- W2393329462 date "2007-01-01" @default.
- W2393329462 modified "2023-09-24" @default.
- W2393329462 title "Evaluation on Alzheimer-like Disease Model Induced by D-galactose and Expression of Galanin in the Hippocampus" @default.
- W2393329462 hasPublicationYear "2007" @default.
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