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- W2393334005 abstract "Objective To observe the effects of tumor necrosis factor-alpha (TNF-α) on the expressions of osteoprotegerin (OPG) in mouse bone marrow stromal MBA-1 cells, and investigate the potential roles of TNF-α in the pathogenesis of osteoporosis. Methods The expressions of OPG mRNA and OPG protein was assayed by RT-PCR and Western blot in BMA-1 cells treated with TNF-α in different concentrations and at different time-periods of cultures. Results (1) OPG was expressed in BMA-1 cell lines. (2) TNF-α downregulated the expression of OPG in BMA-1 cells in a dose-and time-independent manner. (3) 17β-estradiol suppressed the downregulation of TNF-α on the expression of OPG, whereas pyrrodine dithiocarbamete (PDTC) (inhibitor of nuclear factor-κB) had no effects on its downregulation. Conclusions TNF-α enhances osteoclastic bone resorption and bone loss by decreasing the expression of OPG in bone marrow stromal MBA-1 cells. The mechanism involved in the therapeutic effect of estrogen may associate with the suppression of OPG expression, but the signaling pathway that regulates OPG expression by TNF-α is not involved in the activation of nuclear fcator-κB." @default.
- W2393334005 created "2016-06-24" @default.
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- W2393334005 date "2005-01-01" @default.
- W2393334005 modified "2023-09-25" @default.
- W2393334005 title "Effects of tumor necrosis factor-alpha on expressions of osteoprotegerin mRNA and OPG protein in mouse marrow stromal MBA-1 cell lines" @default.
- W2393334005 hasPublicationYear "2005" @default.
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