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- W2393336224 abstract "Objective:To investigate the effects of atorvastatin on vascular fibrosis and connective tissue growth factor (CTGF) in renovascular hypertensive (RH) rats. Methods:The following groups of rats were studied: sham group, RH group and atorvastatin (10 mgokg-1od-1)-treated RH group. Systolic blood pressure (SBP) was measured. The mRNA expression of CTGF, FN and ColⅢ was detected by RT-PCR at the 12th week after operation. The expression of CTGF protein was detected by immunohistochemistry. Results: Compared with the normal control group, the mRNA expression of CTGF (P0.01), FN and ColⅢ (P0.05) in RH group was increased in the thoracic aorta, and atorvastatin could significantly inhibit vascular fibrosis and the expression of CTGF (P0.05). Conclusion: Atorvastatin could inhibit the development of vascular fibrosis in RH rats, which was probably related to the decreased expression of CTGF." @default.
- W2393336224 created "2016-06-24" @default.
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- W2393336224 date "2010-01-01" @default.
- W2393336224 modified "2023-09-23" @default.
- W2393336224 title "Effects of Atorvastatin on Vascular Fibrosis and Connective Tissue Growth Factor in Renovascular Hypertensive rats" @default.
- W2393336224 hasPublicationYear "2010" @default.
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