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- W2393341825 abstract "Objective:To observe the activity changes of NF-κB and CyPA in lung tissues of endotoxin-induction acute lung injury rat and explore the function of NF-κB and CyPA in the pathogenesis of endotoxin-induction acute lung injury.Methods:Randomly separate the 36 rats into 2 groups:Group A:the normal group(n=18):given the equivalent normal saline through tail vein injection;Group B:the lipopolysaccharide group(LPS)(n=18):given 5 mg/kg LPS through tail vein injection;When it's 6 hours,24 hours and 72 hours after molding,collect the sample from the animal which is put to death,6 samples at each time(since one of the 24-hour group of LPS dies,so only the other five are put to death).Determine the wet weight / dry weight of the lung and TNF-α,IL-1β,NF-κB and CyPA in lung tissue.Results:W/D of Group B is obviously higher than that of Group A;There are significant differences between TNF-α,IL-1β,NF-κB,CyPA of different groups by comparing them at the same point of time and that is higher in Group B.Conclusion:NF-κB and CyPA play a importent role in the pathogenesis of endotoxin-induction acute lung injury." @default.
- W2393341825 created "2016-06-24" @default.
- W2393341825 creator A5021386899 @default.
- W2393341825 date "2013-01-01" @default.
- W2393341825 modified "2023-09-23" @default.
- W2393341825 title "Study on Mechanism of LPS-induced Acute Lung Injure" @default.
- W2393341825 hasPublicationYear "2013" @default.
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